Fasoracetam Product Description

Introduction

Fasoracetam is a member of the racetam family of nootropic research chemicals, characterized by its pyrrolidone core structure. This compound appears as a white to off-white crystalline solid and is notable for its potential cognitive-enhancing, anxiolytic, and neuroprotective properties. Fasoracetam has attracted significant scientific interest for its ability to modulate neurotransmitter systems associated with cognition and attention. It is currently under investigation in clinical trials for conditions such as attention deficit hyperactivity disorder (ADHD). Fasoracetam is exclusively used in laboratory and pharmaceutical research settings.

Chemical Properties and Specifications

2.1 Structural and Molecular Characteristics

• Chemical Formula: C10H16N2O2

• Molecular Weight: 196.25 g/mol

• CAS Number: 110958-19-5

• IUPAC Name: (5R)-5-(piperidine-1-carbonyl)pyrrolidin-2-one

• Synonyms: Fasoracetam, NS-105, LAM-105, AEVI-001

2.2 Physical Properties and Purity Standards

• Appearance: White to off-white crystalline powder

• Purity: Typically ≥98% for research grade

• Solubility: Moderately soluble in water and polar solvents; soluble in DMSO and ethanol

• Storage Recommendations: Store in airtight containers in a cool, dry environment protected from light to maintain stability

Pharmacological Profile and Mechanism of Action

3.1 Proposed Mechanism of Action

Fasoracetam modulates neurotransmission by affecting metabotropic glutamate receptors (mGluRs), particularly mGluR group I and II. It also influences cholinergic and GABAergic systems, which are key regulators of memory, learning, and anxiety. By enhancing glutamate receptor function, Fasoracetam may improve synaptic plasticity and neuronal signaling.

3.2 Research Applications

Fasoracetam is used in preclinical and clinical research to explore nootropic effects, synaptic modulation, and treatment potential in neuropsychiatric conditions such as ADHD and cognitive decline. It serves as a model compound for studying glutamatergic and cholinergic interactions in the brain.

Comparative Analysis with Related Compounds

4.1 Comparison with Related Compounds

Unlike traditional racetams that primarily modulate AMPA or NMDA receptors, Fasoracetam uniquely targets mGluRs, offering a different mechanism of cognitive enhancement. It is chemically distinct from piracetam, aniracetam, and other racetams, with a more targeted receptor profile. Its unique attributes provide researchers with diverse options for exploring neurotransmitter regulation.

4.2 Advantages for Research

Fasoracetam’s specificity for mGluRs and favorable pharmacokinetic properties enable detailed receptor and signaling studies. Its stable and high-purity crystalline form supports reliable dosage and reproducibility in experimental settings. The compound’s clinical trial status enhances translational research applications.

Safety and Handling Guidelines

5.1 Laboratory Safety

Use appropriate PPE such as gloves and eye protection when handling Fasoracetam. Work in well-ventilated areas and avoid inhaling dust or vapors.

5.2 Disposal and Environmental Considerations

Dispose of waste according to institutional chemical safety protocols. Avoid environmental release.

5.3 Regulatory Status

Fasoracetam is classified as a research chemical with investigational new drug status in clinical trials. It is not FDA approved for therapeutic use and must be handled in compliance with local regulations.

Frequently Asked Questions (FAQs)

1. What is the molecular formula of Fasoracetam?
   C10H16N2O2.

2. What receptors does Fasoracetam primarily affect?
   Metabotropic glutamate receptors (mGluRs), particularly group I and II.

3. What is Fasoracetam’s purity for research?
   Typically ≥98%.

4. What are the main research applications of Fasoracetam?
   Cognitive enhancement studies, ADHD research, neuropsychiatric condition modeling.

5. How should Fasoracetam be stored?
   In airtight containers, cool, dry, and protected from light.

Conclusion

Fasoracetam is a high-purity racetam-class research chemical that modulates metabotropic glutamate receptors, with promising nootropic and anxiolytic effects. Its unique mechanism and clinical trial engagement make it a valuable compound for neuroscience research and drug development.